Periodontitis: Vitamin D3 as an adjunct therapy?
periodontitis it is a disease that affects both the gums and the periodontium. If left untreated, it can result teeth loosen and subsequently fail. the treatment periodontitis depends on the severity of the disease. It might also help Vitamin D3as scientific studies show.
As explained in an article in “scilog”, the journal of the Austrian Science Fund FWF, periodontitis is an inflammatory disease of the periodontium. Treatment and regeneration present a major challenge to dentistry. Cell biologist Oleh Andrukhov looks for dental stem cells interacting with the immune system. His data shows that vitamin D3, among other things, plays a crucial role here.
Oral cavity colonized by various bacteria
The portal of entry into the body is the oral cavity colonized by a particularly large number of different bacteria. Most of them are useful for humans, the body’s immune system can usually defend itself well from less useful rest.
But take the specific ones bacteria prevails, a weakened immune system is no longer able to fight pathogens. This condition can lead to periodontitis, which can lead to chronic inflammation of the periodontium and, if left untreated, eventually to tooth loss.
The big picture of this complicated Inflammatory process The underlying interaction has now been enriched by a piece of the puzzle thanks to the Austrian researchers.
Different immunomodulatory abilities
“We know that so-called dental mesenchymal stem cells (MSCs) play an essential role.”explains Oleh Andrukhov of the Vienna University Dental Clinic. “So far we have mainly considered them as a useful tool for tissue regeneration. But they also have the ability to influence immune cells. So they have an immunomodulatory effect “.
Recent studies have suggested that MSCs are different immunomodulatory abilities to possess. However, these differences have never been systematically studied. A team led by cell biologist Oleh Andrukhov has now taken on this task.
Furthermore, the researchers hypothesized that the interaction of dental MSCs with immune cells plays an essential role in periodontitis. They also looked at the influence of vitamin D3 on this interaction. The reason for this: “It has long been assumed that a Eat a vitamin D3 a Risk factor for periodontitis “.
Perfectly balanced system found
Scientists isolated for investigation blood cells from dental and in general physically healthy, as well as mesenchymal subjects stamina cells (progenitor cells) from extracted (pulled) teeth.
“In order to study the interaction between stem and immune cells and vitamin D3, we developed our model”explains Andrukhov. Together with his team, he has found a perfectly balanced system. “There is a constant, two-way interaction between immune cells and dental stem cells.”
This interaction is usually self-balancing, but ultimately depends on the local ones conditions of the oral cavityespecially the presence of proinflammatory cytokines (transmitters of immune cells).
On the one hand, the production of cytokines by immune cells activates dental MSCs, and on the other hand, dental MSCs suppress the activity of immune cells, which leads to less cytokine production. According to the professionals, a balance of these interaction be essential for the progression of periodontitis and for the regeneration of dental tissue.
Vitamin D3 in higher doses as adjunct therapy
Furthermore, the data showed that this balanced interaction between immune cells and dental MSCs are affected by vitamin D3 in various ways.
As explained in the article, vitamin D3 inhibits the activity of various immune cells and thus reduces the production of pro-inflammatory cytokines. And at the same time, vitamin D3 also inhibits them immunomodulatory activity by MSC Dental.
These properties of vitamin D3 are in turn inhibited by bacterial factors as well as by cytokines regulated. Therefore, vitamin D3 influences local conditions and at the same time its bioactivity is modulated by these conditions.
This suggests that vitamin D3 is consumed in higher doses of adjunct therapy it could be used in periodontitis and, in turn, the effectiveness of vitamin D3 could be improved by changing local conditions.
“However, optimal conditions have yet to be sought”, according to Andruchov. In any case, the results open a new perspective for future research projects.
The researchers’ previous findings have been published in the “Journal of Periodontal Research”, “Journal of Clinical Periodontology”, “Cells” and “World Journal of Stem Cells”. (A.D)
Information on the author and source
This text corresponds to the specifications of the specialist medical literature, medical guidelines and current studies and has been verified by medical professionals.
- scilog, journal of the Austrian Science Fund FWF: New approaches to the treatment of periodontitis, (accessed: 22 June 2022), scilog
- Blufstein A., Behm C., Kubin B., Gahn J., Moritz A., Rausch-Fan X., Andrukhov O .: Effect of vitamin D3 on osteogenic differentiation of human periodontal ligament stromal cells in inflammatory conditions; in: Journal of Periodontal Research, (veröffentlicht: 05.02.2021), Journal of Periodontal Research
- Behm C., Blufstein A., Gahn J., Kubin B., Moritz A., Rausch-Fan X., Andrukhov O .: Pleiotropic effects of vitamin D3 on CD4 + T lymphocytes mediated by human periodontal ligament cells and the environment inflammatory; in: Journal of Clinical Periodontology, (veröffentlicht: 11.03.2020), Journal of Clinical Periodontology
- Behm C., Blufstein A., Gahn J., Nemec M., Moritz A., Rausch-Fan X., Andrukhov O .: Cytokines differently define the immunomodulation of mesenchymal stem cells from the periodontal ligament; in: Celle, (veröffentlicht: 14.05.2020), Celle
- Andrukhov O., Behm C., Blufstein A., Rausch-Fan X .: Immunomodulatory properties of tooth-derived mesenchymal stem cells: Implication in disease and tissue regeneration; in: World Journal of Stem Cells, (veröffentlicht: 26.09.2019), World Journal of Stem Cells
This article contains general advice only and is not to be used for self-diagnosis or treatment. It cannot replace a visit to the doctor.