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Thrombosis after vaccination: decoded cause – healing practice

How a wrong immune reaction can cause thrombosis

As a result of course vaccinations with adenovirus vaccines there is a minimal risk of developing thrombosis. According to German Heart Foundation such complications occur one to two people for every 100,000 vaccinated On. A German research group is currently investigating how Thrombosis occurs after vaccination being able.

A working group of the Medical Clinic and Polyclinic I: Cardiology at the LMU Clinic in Munich Dr. Leo Nicolai A study investigates how Thrombosis occurs in rare cases after vaccination with adenovirus-based vaccines being able. The team is now reporting their findings so far in the trade journal “Blood”.

Thrombosis in COVID-19 vaccinations

In COVID-19 vaccinations with the Vaxzevria vaccine of Astra Zeneca and the vaccine from Johnson & Johnson In very rare cases, vaccination complications in the form of thrombosis have occurred after vaccination; cerebral veins were often affected. Among other things, for this very reason have not used these vaccines in Germany since December 2021.

“For the development of future vaccines and the safety of people susceptible to thrombosis, including patients with cardiovascular disease, it is important to understand the causes and mechanisms of these rare thromboses as a wrong immune reaction – here in the context of a vaccination.”explained professor Dr. Thomas Voigtlander. He is chairman of the board of directors of the German Heart Foundation.

“Importantly, when it comes to protecting against the consequences of a Covid-19 infection, the benefit is still clearly on the side of Covid vaccination – although in rare cases severe side effects sometimes occur with mRNA.” or Covid-vector vaccines “emphasizes cardiologist Voigtländer.

What does VITT mean?

Induced by vaccination blood clot in atypical places such as brain veins are in medical jargon with the abbreviation WHITE denotes what “Vaccine-induced immunothrombotic thrombocytopenia“stands. It means one wrong response of the immune system.

Platelets (thrombocytes) play a crucial role in this process. Normally, they serve to quickly close injuries to blood vessels in order to prevent bleeding. Another task of platelets is to react to invaders. These include, for example Pathogens such as viruses and bacteriabut also Active ingredients from medicines.

Platelets react to the components of the vaccine

As the researchers report, platelets react to vaccine components. A certain platelet proteins with the label Platelet factor 4 (PF4) it is activated by the vaccine.

That immune system in turn responds to it by Forms antibodies against PF4 and yourself in a row latching on. One can aggregation of platelets you get up and a thrombosis forms.

Drop in platelet count after adenovirus drugs

According to the research team, after vaccination with adenovirus-based substances delayed fall in platelet count (thrombocytopenia). “A misalignment of your immune system against blood platelets”confirms Nicolai.

The exact mechanisms leading to VITT are currently being studied in detail by the working group led by Dr. Nicolai Enlightened. “Based on further investigations into the exact reaction mechanisms, we want to help make vaccinations with adenovirus-based techniques even safer overall in the future.”Nicolai explains.

Not only relevant to vaccines

The focus isn’t just on AstraZeneca or Johnson & Johnson’s COVID-19 vaccines. A similar reaction was, for example, after the administration of the anticoagulant heparin known.

Performing the injection affects the risk of thrombosis

Furthermore, the team was able to demonstrate in preliminary in vivo tests for the study that the risk of immune overreaction after vaccination with adenovirus vaccines increases if Accidentally hitting a blood vessel while injecting. This is not the case with proper application in the muscle.

“We are convinced that this project will help better understand the interaction of platelets and the immune system in other cardiovascular diseases and thus make a forward-looking contribution to basic research and heart health.”, summarizes Professor Voigtländer. (vb)

Information on the author and source

This text corresponds to the requirements of the specialist medical literature, medical guidelines and current studies and has been verified by medical professionals.

Author:

Graduate Publisher (FH) Volker Blasek

Sources:

  • Deutsche Herzstiftung eV / German Foundation for Heart Research: From “helper” to “enemy”: blood platelets can cause thrombosis due to a wrong immune reaction (published: 23 June 2022), idw-online.de
  • Leo Nicolai, Alexander Leunig, Kami Pekayvaz, et al .: Thrombocytopenia and direct immune responses to splenic platelets after intravenous administration of ChAdOx1 nCov-19; in: Blood (2022), ashpublications.org

Important note:
This article contains general advice only and is not to be used for self-diagnosis or treatment. It cannot replace a visit to the doctor.

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