Health

The risks of corona increase with repeated infection

If you take a closer look at the authors’ data, you can see that people with reinfections double the risk of dying from Covid-19 as well as cardiovascular and pulmonary complications compared to those with just one infection. The risk of being hospitalized even triples. True, the highest likelihood of these unwanted results is immediately after reinfection. However, the risk for most of these complications remains and tends to decrease for up to six months. There were increased risks to all of these vital functions regardless of whether patients received one or more vaccinations prior to the second infection. The study was previously published online as a so-called preprint and has not yet been reviewed by experts.

This is a new quality of risk associated with the appearance of the omicron variant. While reinfections before the omicron wave were quite rare at <1% up to the delta wave, they now occur much more frequently. This is due to the high immune escape potential of omicron variants BA.2, BA.2.12.1, BA.4 and BA.5, which means that immune protection after an infection has been experienced is bypassed in very efficient way.

Ultimately, this study clearly demonstrates that reinfection is not trivial in terms of all-cause mortality, hospital stays, and adverse health consequences in the acute and post-acute phases. Therefore, reinfection prevention strategies are urgently needed to reduce the overall burden of death and disease from SARS-CoV-2, the authors conclude.

For their analysis, the authors use data from the U.S. Department of Veterans Affairs national health databases. They define three different cohorts:

  • people who had been infected once (257,427 participants),
  • People who had recovered from Covid-19 at least twice (38,926 participants) e
  • People not yet infected (control group, 5,396,855 participants).

Which: DOI 10.21203 / rs.3.rs-1749502 / v1

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