Influence of diet on the intestinal microbiome
Diet has a significant impact on this Darmmicrobial (Darmflora). Not only does what and how much you eat play an important role, but the time you eat is also essential.
In a new study involving experts from University of California – San Diego studied the effects of diet and feeding times on the composition of the gut microbiome and on the RNA (transcriptome) molecules produced in the cells of mice. The results were published in Cell Reports.
trillions of microorganisms in the gut
Estimated life in the intestines of humans 500 to 1,000 types of bacteria and a total of approx 100,000 trillion microorganisms, the researchers report. Using a mouse model, they have now studied how diet and feeding patterns affect these gut microbes.
Furthermore, the effects of the Changes in the gut microbiome animal health, in particular obesity and type 2 diabetes.
What happens in the ileum and the cecum?
In mice and humans, the so-called Ileus represents the last section of the small intestine.This section is connected to the cecum, which is the first part of the large intestine.
In the ileum the Nutrients extracted from liquefied food and in the so-called cecum, which marks the beginning of the large intestine, the dehydration processexplains the team.
Both processes are extremely complex, dynamic and strongly influenced by many factors. These range from the type and the time of food intake up to this microbial composition in the intestine.
The gut microbiome affects, among other things digestiondie nutrient intakedie Vitamin synthetics and the development of the immune system.
Changes in the gut microbiome over the course of the day
“It is important to recognize that the gut microbiome is constantly evolving, not only based on what we eat, but also based on the time of day.‘explains the author of the study Dr. Amir Zarrinpar in a press release.
Weaknesses of Previous Research
The expert further reports that in most of the searches so far only one snapshot valued in this ever-changing environment. This makes it difficult to understand what exactly is going on in the gut.
The current study uses against it several snapshots scattered throughout the dayto better analyze how food and the microbiome interact to affect body weight and diabetes.
The team paid particular attention to how the diet was related Obesity and limited-time feeding the composition of ileal microbiome and transcriptome influence.
Weight gain due to disruption of the intestinal microbiome
Diet-induced obesity and time-limited lack of nutrition have been found to increase in mouse models Disturbances of intestinal microbiome rhythms carried. In addition, important signaling pathways were disrupted, resulting in the The animals have gained weight and their health has deteriorated.
Temporarily limited food intake
According to the author of the study, there is a time limit for access to food Dr. Ana Carolina Dantas Machado clearly positive effects on the composition of the intestinal microbiome of animals and on the altered signaling pathways.
The study underscores the importance of time-limited diet and feeding patterns in maintaining a healthy gut microbiome, which in turn modulates the circadian rhythms (called the biological clock) that govern metabolic health.
To die cyclical changes in the gut microbiome According to the research team, support the circadian rhythm and thus the regulation and control of glucose, cholesterol and fatty acidswhich has a positive effect on overall metabolic health.
“It is a very complicated relationship between the microbiome and the host, with the microbiome co-determining the gastrointestinal function and the health of the host.“, He summarizes Dr. Amir Zarrinpar. (how)
Information on the author and source
This text corresponds to the specifications of the specialist medical literature, medical guidelines and current studies and has been verified by medical professionals.
- Ana Carolina Dantas Machado Steven D. Brown Amulya Lingaraju Vignesh Sivaganesh Cameron Martino, et al .: Diet and feeding patterns modulate diurnal dynamics of the ileal microbiome and transcriptome; in: Cell Reports (veröffentlicht Volume 40, ISSUE 1, 05.07.2022), Cell Reports
- University of California – San Diego: a rhythmic microbiome of the small intestine prevents obesity and type 2 diabetes (veröffentlicht 05.07.2022), University of California – San Diego
This article contains general advice only and is not to be used for self-diagnosis or treatment. It cannot replace a visit to the doctor.