Health

The current international in vitro study demonstrates the multi-target effect of benzyl mustard oil against MRSA

Eschborn – Antibiotic-resistant germs were responsible for at least 1.2 million deaths worldwide in 2019, according to a recent meta-analysis published in The Lancet.[1]. To counter the problem of resistance, for many years experts have been calling for antibiotics for simple infections such as urinary and respiratory infections, but prefer proven antibacterial plant substances such as mustard oils (isothiocyanates) from nasturtium and horseradish (in ANGOCIN® Anti-infection n) as first-line therapy[2]. A new international in vitro study now provides further evidence that the benzyl mustard oil contained in nasturtium also has a pronounced antibacterial effect against problem germs such as MRSA (Methicillin-resistant Staphylococcus aureus) hat[3]. Already before In vitro-Studies at the University of Friborg[4] as well as numerous international research papers[5-7] confirm the broad spectrum of antibacterial effects of mustard oils, even against dangerous bacteria such as MRSA, Klebsiella, vancomycin-resistant enterococci (VRE) or resistant Escherichia coli (E. coli)-tribe. “The use of herbal medicine in acute and uncomplicated infections of the urinary and respiratory tract can make an important contribution to stopping the deadly threat of resistant pathogens,” says microbiologist and hygienist Prof. Uwe Frank, Freiburg, responsible for basic research on the carried out mustard oils.

Antibiotic resistance is one of the main causes of death in the world and therefore one of the greatest threats to human health, as the authors of the analysis published in the Lancet clarify.[1]. According to this, in 2019 more than 100,000 deaths worldwide were due to infections alone MRSA attributed. MRSA it is one of the pathogens that most often cause resistance problems. The germ is a frequent and dangerous cause of nosocomial infections. A recent US study also demonstrates this MRSACarriers: have significantly increased mortality rates[8]. For example, those who carried the bacterium on their skin, usually unknowingly, had double the risk of dying within the next 10 years since MRSA– Not carriers. In study participants who wore staph on their skin, but not MRSAthere was no increased risk of premature death.

Extended study situation – broad spectrum of antibacterial activity

Nasturtium and horseradish mustard oils have been used in traditional medicine for centuries to treat urinary and respiratory tract infections. Numerous studies demonstrate the broad spectrum of the antibacterial effects of plant substances[4-7]. In the current study of the University of Shaanxi / China[3] the benzyl mustard oil from nasturtium was able to inhibit the growth of MRSA– They contain pathogens. In a previous study by Portuguese scientists, benzyl mustard oil was even found to have a pronounced bactericidal effect MRSA established[7].

In vitroStudies from the University of Freiburg confirm that the combination of nasturtium and horseradish mustard oils has a pronounced germ-inhibiting effect on all 13 pathogens of respiratory and urinary tract infections analyzed in the study and relevant in practice[4]. Next to MRSA there were, among other things, streptococci, VRE and the formation of ESBL E. coli And Klebsiella pneumoniae analyzed. The investigations of the researchers from Freiburg also showed that the combination of the two plants and the mustard oils contained in them (mixing ratio as in ANGOCIN® Anti-infection n) complement each other in their effects and thus a particularly broad spectrum of antibacterial effects can be obtained. In addition, plant substances inhibit uropathogens E. coli (UPEC) as well as their adhesion and motility and prevent the formation of bacterial biofilms – a bacterial mechanism that is often associated with recurrent urinary tract infections[9-12]. Due to the multimodal effects of mustard oils, the development of possible resistance mechanisms in bacteria is significantly more difficult[13-15]. “In view of the dramatic development of resistance and the search for new antimicrobial substances that do not cause resistance, the anti-infective potential of mustard oils is therefore of great value,” sums up Frank. Furthermore, numerous other research projects certify that phytotherapy has a pronounced anti-inflammatory effect, which contributes significantly to the improvement of symptoms of acute respiratory and urinary tract infections.[16-18].

Nasturtium and horseradish root recommended in two guidelines

Based on comprehensive scientific data on the efficiency of nasturtium and horseradish mustard oils, their use has been

2017 recommended in guideline S3 “uncomplicated urinary tract infections” for recurrent cystitis[19]. The good study situation and the tolerability of the mustard oil mixture has also been taken into consideration since 2021 by the updated S2k guideline “Urinary tract infections in childhood”. Guidelines Recommend: Nasturtium and horseradish mustard oils can be used as a supportive measure in uncomplicated recurrent cystitis in late childhood and adolescence[20].

ANGOCINA® Anti-infection n

Areas of application: To improve the symptoms of acute inflammatory diseases of the bronchi, sinuses and urinary tract. Composition: 1 film-coated tablet contains: 200 mg nasturtium herb, 80 mg horseradish root. Other Ingredients: Cellulose, iron oxides and hydroxides E 172, hypromellose, potato starch, macrogol, sodium carboxymethyl starch, colloidal silica, stearic acid, talc, titanium dioxide E 171. Contraindications: Acute ulcers of the stomach and intestines and / or acute inflammation of the kidneys, allergy to nasturtium grass, horseradish root or any of the other ingredients. Side effects: Common: stomach and intestinal problems such as nausea, upper abdominal pressure, diarrhea, flatulence or heartburn. Uncommon: systemic allergic reactions and skin hypersensitivity reactions (e.g. flushing, rash and / or itching). Pharmaceutical Entrepreneur: Repha GmbH Biological medicines, Alt-Godshorn 87, 30855 Langenhagen.

Literature:
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