Reduce obesity without moving
Identifying an exercise-produced molecule in the blood could help reduce food intake by fighting obesity in the future. Furthermore, the development of a Drug be made possible that the teaches the benefits of sportwithout having to move.
In a new study involving experts from Stanford School of Medicine studied which molecular and cellular mechanisms mediate the metabolic benefits of physical activity.
The results were published in the English-language journal “Nature”.
What is Lac Phe?
In their investigation, the researchers performed thorough Analysis of blood plasma compounds of mice after intensive training on a treadmill. It turned out that a most affected molecule was a modified amino acid with the designation Lac-Phe is.
Lac-Phe is off lactate (a byproduct of strenuous exercise which is responsible for the burning sensation in the muscles) e Phenylalanine (amino acid, which is one of the building blocks of protein), the team explains.
Physical activity helps with weight loss
“Regular exercise has been shown to help lose weight, regulate appetite and improve metabolic profile, especially in overweight and obese people‘explains the author of the study Professor Dr. Yong Xu in a press release by Baylor College of Medicine.
Understanding how exercise triggers these benefits could help many people to improve their health, continues the doctor. “We wanted to understand how motion works at the molecular level in order to take advantage of some of its benefits‘adds the study’s author Dr. Jonathan Long added.
Benefits of Exercise While Taking a Medication
According to Dr. A long day, for example, in the elderly or infirm who are no longer able to move adequately, from taking a drug the progression of osteoporosis, heart disease or to slow down other diseases.
50 percent less food intake thanks to Lac-Phe
The study showed that a high doses of Lac-Phe in obese mice, the intake of the high-fat diet consumed by the animals over a 12-hour period increased by approximately 50 percent suppressed compared to mice from a control group. According to the team, neither movement nor energy consumption was affected.
Lower body weight and better glucose tolerance
It was administered to the animals for a period of ten days Lac-Phe administered reduced the cumulative food intake and body weight (due to the loss of body fat) and, at the same time, glucose tolerance has improved, the experts add.
Furthermore, the team also managed to create an enzyme called CNDP2 to identify who is involved in the production of Lac-Phe. The research team found that mice lacking this enzyme did not lose as much weight from an exercise program as did a control group with the same exercise regimen.
The findings also appear to apply to humans and horses
There is also one in humans and racehorses strong increase in plasma levels of Lac-Phe after exercise, the researchers report. For example, data from a human training cohort showed this sprint training showed the greatest increase in plasma Lac-Phe levels caused, followed by resistance training and resistance training.
Lac-Phe as a nutritional regulation system
“This suggests that Lac-Phe is an ancient and preserved system that regulates nutrition and is associated with physical activity in many animal species“, has explained Dr. Long.
“Our next steps are to find more details on how Lac-Phe mediates its effects in the body, including the brain. Our goal is to understand how to modulate this motor path for therapeutic interventions‘adds the study’s author Professor Dr. Xu added.
Further research in this area may someday lead to aa drug which conveys the health benefits of exercise and concomitant weight loss without involving the people who actually need to exercise. (how)
Information on the author and source
This text corresponds to the specifications of the specialist medical literature, medical guidelines and current studies and has been verified by medical professionals.
- Veronica L. Li, Yang He, Kévin Contrepois, Hailan Liu, Joon T. Kim, et al .: An exercise-inducible metabolite that suppresses nutrition and obesity; in: Nature (veröffentlicht 15.06.2022), Nature
- Baylor College of Medicine: The Benefits of Exercise in a Pill? Science is closer to this goal (veröffentlicht 15.06.2022), Baylor College of Medicine
This article contains general advice only and is not to be used for self-diagnosis or treatment. It cannot replace a visit to the doctor.