Resistance: Multi-resistant cheering spreads around the world

Typhoid pathogens, resistant to several groups of antibiotics, have become more common since 2016 and are spreading internationally. A working group led by Kesia Esther da Silva of Stanford University came to this conclusion on the basis of a genetic analysis of thousands of samples of the bacterium. Salmonella enterica serotype Fans (S. supporters). As reported now in The Lancet, resistance to important antibiotics such as ciprofloxacin and azithromycin continued to emerge in South Asia and spread through international travel routes between countries and continents.

Typhus is more common in South Asia, where it occurs in about 70% of cases. To find out how antibiotic resistance develops there, the team sequenced the genomes of 3,500 bacterial strains that had infected people in India, Pakistan, Nepal and Bangladesh between 2014 and 2019. In addition, the team compared them to genomes. global rooting to see if such dangerous strains are spreading internationally.

S. Typhi causes severe diarrheal diseases that kill more than 100,000 people every year. If you take them, antibiotics usually work well against the pathogen, at least for now. There is an effective vaccine against S. Typhi, which the World Health Organization recommends only where antibiotic resistance is very common.

According to the working group’s investigations, South Asia is a center of resistance development and also repeatedly exports potentially dangerous pathogens. New resistances have emerged nearly 100 times independently of each other against the important class of antibiotics known as fluoroquinologists alone. In addition, a salmonella strain known as XDR Typhi (extended drug resistance) with a whole collection of resistances was detected in Pakistan in 2016, which has since supplanted most of the other local strains. Some XDR Typhi isolates can only be fought with the active ingredient azithromycin.

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