Approach to pancreatic regeneration
to Diabetes the body often cannot do enough Insulin produce al blood sugar levels quite low. Those affected are therefore often dependent on the injection of insulin. A new therapeutic approach aims to stimulate the insulin-producing cells of the pancreas to regenerate so that enough endogenous insulin can be produced again.
researchers of Karolinska Institute in Sweden they deciphered a mechanism that could stimulate the pancreas to form new insulin-producing cells. The research results were recently presented in the renowned journal “Nature Chemical Biology”.
Insulin balance plays a central role in diabetes
Insulin is a hormone needed to absorb sugar (glucose) from the blood. High blood sugar levels are characteristic of type 1 and type 2 diabetes. High blood sugar is on one Lack of endogenous insulin due to or the inability to use the released insulin.
Diabetes is currently not curable
Although diabetes can be controlled by a healthy lifestyle with an adapted diet, insulin injections or hypoglycemic drugs, metabolic disease cannot be cured according to the current state of knowledge.
“We are therefore researching the possible regeneration of insulin-producing β cells in the pancreas”explains the first author of the study Christ Carampelia.
New approach to diabetes therapy
The Swedish research team has now presented its latest study results, that diabetes care therapy could have come within reach. The team identified a mechanism for Renewal of β cells in the pancreas.
“Our results point to a potential new target for diabetes treatment.”confirms the lead researcher Dr. Olov Andersson. The goal is to regulate blood sugar levels by stimulating the pancreas to produce more beta cells and consequently more insulin.
A molecule stimulates the production of β cells
In a previous study, the team from the Karolinska Institutet had named a molecule CID661578 identified that the Regeneration of insulin-producing beta cells can stimulate. In the ongoing work, the researchers have been able to decode the mechanisms behind this process.
Insulin production could be increased
As the team found out, it ties in MNK2 protein names to the discovered molecule. The binding stimulates certain processes that stimulate the formation of new beta cells in the pancreas.
In zebrafish, pigs, and human organoids, the Insulin production may already be increased by the newly discovered molecule.
Not yet tested on humans
‘We will now examine the effect of this and similar molecules in human tissue and analyze the molecule’s target protein, MNK2, in the tissue of healthy donors with diabetes.’, explains Dr. Andersson the next steps. (vb)
Information on the author and source
This text corresponds to the requirements of the specialist medical literature, medical guidelines and current studies and has been verified by medical professionals.
Graduate Publisher (FH) Volker Blasek
- Karolinska Institutet: The study describes a new way of generating insulin-producing cells (veröffentlicht: 13.06.2022), news.ki.se
- Karampelias, C., Watt, K., Mattsson, CL et al. MNK2 deficiency enhances β cell regeneration through translational regulation. Nat Chem Biol (2022). https://doi.org/10.1038/s41589-022-01047-x, natura.com
This article contains general advice only and is not to be used for self-diagnosis or treatment. It cannot replace a visit to the doctor.