- Antibiotic resistant Typhus-Erreger go global Danger
- Current study: Dangerous pathogen of diarrhea it is spreading more and more all over the world
- Reason: International travel and late fighting
- The researchers have a clear recommendation: Bet on the vaccinebefore resistance can develop
Resistant to antibiotics Tifo-Erreger have been spreading around the world since 2016. That one now has one recent study by Stanford University researchers shown. Scientists refer to one Genetic analysis of thousands of samples of the bacterium Salmonella enterica serotype Typhi (S Typhi).
S Typhi: severe diarrheal disease – which can be fatal
In the trade magazine “The hand” the study has now been published and researchers report it again and again in South Asia Resistance to the main antibiotics such as ciprofloxacin and azithromycin re-emerge. These then spread mainly through international travel Worldwide.
S Tifi caused in most cases extremely severe diarrheal diseasesattended every year more than 100,000 people die worldwide. If you do get infected with the pathogen, antibiotics work well for the most part, for now.
There is also a effective vaccine against S TyphiLa la World Health Organization (WHO) but recommended only where antibiotic resistance is very common. So not everyone who wants to protect themselves can get vaccinated against the pathogen.
Widespread in Southeast Asia: how did antimicrobial resistance arise?
With more than 70 percent is the spread of typhus by far the largest in Southeast Asia. To find out how antibiotic resistance develops there, the team sequenced it Genome of 3500 strains of bacteriawhich infected people in India, Pakistan, Nepal and Bangladesh between 2014 and 2019.
Furthermore, the researchers compared the Bacterial strains with worldwide typhoid genometo see if such dangerous strains are spreading internationally. The result: Yes, the tribes are spreading. According to the researchers, the pathogen is repeatedly “exported” particularly from Southeast Asia.
Alone against them important class of fluoroquinolone antibiotics According to the study, the new resistances developed nearly 100 times independently of each other. Also, in 2016, a Salmonella strain called XDR Typhi (broad drug resistance) was identified in Pakistan. a whole series of resistances tried, which has already moved most of the other tribes there. Some XDR Typhi isolates can only be fought with the active ingredient azithromycin. In 2013, a mutation appeared in Bangladesh that renders S Typhi insensitive to azithromycin. According to the researchers, this line of bacteria has spread steadily since then.
Relying on a vaccine: Researchers make a clear recommendation
Such resistant bacteria probably distributed around 200 times internationally, even in 60 cases from continent to continentis[calledGreatPartofOpportunityNoiseinparticular[chiamatoGranpartedelrapportorumorosoinparticolare dangerous bacterial line H58 landed in the UK. H58 revealed the analysis over 98 percent of multi-resistant lines.
The study provides the so far the broadest genome analysis of typhus pathogens Based on the findings, the researchers recommend relying much more on the vaccine and not waiting until antibiotic resistance develops before fighting the pathogen.
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