How the gut microbiome affects the course of heart failure
A lack Diversity of microorganisms in the intestine According to a current review, the course of Heart failure (heart failure) affect negatively. sick with one unbalanced intestinal flora must therefore more often in the hospital be admitted and have a increased risk of death due to heart disease.
researchers of Georgetown University Medical Center in Washington DC (USA) have collected evidence from over 500 studies showing that a lower biodiversity of microorganisms in the intestine With more severe courses of heart failure connected is. The results of the review were recently featured in Heart Failure Reviews.
The intestine houses an entire ecosystem
Our Darmmikrobiomoften like “Darmflora“, It is a finely balanced ecosystem consisting mainly of many different types of bacteria. In addition, various viruses, fungi and protozoa also settle in the intestine.
Previous studies have already shown that the intestinal flora central role in human health plays. The metabolic products produced by intestinal bacteria are necessary for the body to stay healthy.
The intestinal flora is even connected to the brain via the so-called gut-brain axis. The working group of Georgetown University Medical Center has now shown that the microbiome in the gut also affects the Course of cardiovascular diseases can influence.
The intestinal flora is not considered sufficient in medicine
“We rely on certain test results and results to diagnose and treat heart failure, but we don’t know how poor heart function affects bowel activities.”explains the author of the corresponding study Professor Dr. Kelley Anderson.
According to her, it has not yet been considered how ingested food and drugs change the intestinal flora and how a change in the intestinal flora affects the course of the disease.
Interactions between intestinal flora and cardiovascular system
“There is now an understanding of an interconnected relationship between the heart and the elements in the gut, since the heart and vascularity clearly don’t function in isolation.”Professor Anderson points out.
The health of the cardiovascular system can affect the health of the intestinal flora and vice versa. Clear evidence of this is currently being developed in current studies.
The link has been suggested in 511 studies
In recent years, the most advanced technologies have made it possible to better understand the complex relationship between microorganisms in the intestine and human health.
The team collected and evaluated 511 research paperswhich were released between the years 2014 and 2021. In all articles, a Relationship between the gut microbiome and heart health suggested. Scientists have discovered 30 studies of particular relevance.
Effects of some metabolites of intestinal bacteria
An example of the link is a called metabolite Trimethylamine-N-oxide (TMAO) – a metabolite of some intestinal bacteria which can affect cardiovascular health.
TMAO rose when Consumption of whole dairy products, egg yolks and red meats product if one unbalanced intestinal flora gift.
Diet affects intestinal flora and heart health
The researchers point out that the nutrition it is an important part of overall cardiovascular health. The composition of the gut microbiome is also influenced by nutrition.
However, the subtleties of this interaction are still not sufficiently understood. according to Dr Anderson is currently conducting studies examining how the use of Antibiotics, prebiotics and probiotics affect the microbiome in the gut.
Read the severity of heart disease from the gut flora
Overall, the working group sees great potential in influencing the gut flora for the treatment of heart disease such as heart failure.
“We are currently developing a pioneering study to evaluate the microbiome in heart failure patients”, summarizes the study’s author. (vb)
Information on the author and source
This text corresponds to the specifications of the specialist medical literature, medical guidelines and current studies and has been verified by medical professionals.
Graduate Publisher (FH) Volker Blasek
- Georgetown University Medical Center: lack of diversity of microorganisms in the gut or elevated metabolite implicated in the severity of heart failure (veröffentlicht: 20.06.2022), eurekalert.org
- Kelley M. Anderson, Erin P. Ferranti, Emily Couvillon Alagha, et al .: The heart and gut relationship: a systematic review of the evaluation of the microbiome and trimethylamine-N-oxide (TMAO) in heart failure; in: Heart Failure Reviews (2022), link.springer.com
This article contains general advice only and is not to be used for self-diagnosis or treatment. It cannot replace a visit to the doctor.