Corona vaccination protects in all weight classes

Obesity is a major risk factor for severe Covid-19 and weakens the immune system. Conversely, vaccination protects in all “weight classes”. This is the result of a study with data from nine million people in Great Britain. Another scientific study showed that temporarily stopping immunosuppressive drug therapy for rheumatism enhances the effect of SARS-CoV-2 vaccines.

In the treatment of immunocompromised rheumatism, a break after vaccination may be advisable

In the treatment of immunocompromised rheumatism, a break after vaccination may be advisable

“One in five people worldwide are at particular risk of a severe course of SARS-CoV-2 infection due to additional health burdens. There is consistent evidence that obesity is a significant independent risk factor,” they said. written Carmen Piernas and her co-authors in Lancet diabetes and endocrinology ( Furthermore, there appears to be a correlation between obesity and a weaker response to vaccination.

Data evaluated by over 9 million people

For the scientific study, the experts then evaluated data from 9,171,524 people who were enrolled in family doctor studies in England under the National Health System (NHS). The observation period runs from 8 December 2020, the year in which the first vaccinations against Covid-19 were carried out in England, to 17 November 2021. The information was analyzed according to different “weight classes”: a BMI (Body Mass Index) below 18.5 (underweight), BMI 18.5 to 24.9 (normal weight), overweight: BMI 25 to 30 and obese (BMI over 30). The mean age was 52 years, the mean BMI 26.7. This also means that people in England are on average overweight.

As experts documented, all people who had been vaccinated at least twice against Covid-19 had a high protection factor against hospital admissions following Covid-19: this risk was reduced by 49 percent in underweight people. two weeks after immunization and 66 percent in people of normal weight, among the 68 percent overweight. The effect of vaccination among the obese was equal to that of the overweight. The death protection rate from Covid-19 was 40 percent for the underweight, 61 percent for the normal weight, 70 percent for the overweight and 74 percent for the obese. Part of the lower SPF among the underweight may be due to the lower vaccination coverage in this group. There should be more efforts to promote vaccination there, the scientists wrote.

Methotrexate reduces the effectiveness of the vaccine

British scientists recently published an important discovery in “Lancet Respiratory Medicine” (DOI: 10.1016 / S2213-2600 (22) 00186-2; June 27). Many people suffer from chronic inflammatory diseases and receive – for example in case of rheumatoid arthritis (“joint rheumatism”), psoriasis etc. – drugs to weaken the immune system. Here, low doses of the cytostatic methotrexate, previously used primarily in oncology, are most frequently used. For example, it is one of the most important effective drugs in the treatment of chronic polyarthritis. But on immunosuppressive therapy, people respond less well to vaccinations.

British scientists have now tested a possible way out of vaccination against Covid 19. Since autumn last year, they have hospitalized 254 patients with rheumatoid arthritis (about half), psoriasis (34%) and other chronic inflammatory diseases. All were treated with methotrexate. After the third partial vaccination against Covid-19, methotrexate therapy was then suspended for two weeks in 50 percent of these people.

Then, from the University of Nottingham, Abhishek Abhishek and his team of authors measured the antibody response in the two groups of subjects. It was found that patients with a methotrexate rupture developed slightly more than twice the antibody response at the third partial Covid 19 vaccination than those who continued to be treated with the cytostat. On the other hand, up to three months after stopping MTX therapy, chronic inflammatory disease rekindled in just over 70 percent of the subjects. However, these flare-ups were mild and easily manageable. However, this procedure should always be discussed and discussed with the doctor treating you.

(APA / red, Photo: APA / APA / dpa / Moritz Frankenberg)

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