Updated: 6/15/2022 – 3:21 pm
Slow down mutations
ASA can slow the spread of colon cancer
According to a recent study, acetylsalicylic acid (ASA), used to treat pain and mild fever, can also slow the spread of colon cancer.
Colorectal cancer is one of the most dangerous forms of cancer, as symptoms often only appear when the disease is already in an advanced stage. This is why regular checkups are particularly important. A well-known and widely used pain reliever now appears to be an option as a treatment option. According to a recent study, the pain reliever ASA (acetylsalicylic acid) is said to be able to slow the progression of the disease.
ASA can slow the growth of colon cancer
ASA is mainly used for mild pain such as headache, but also for fever. The active ingredient also has anti-inflammatory properties. The results of a US study now show that taking ASA prevents colon cancer cells from multiplying and also makes their survival more difficult. ASA slows down the division of cancer cells and at the same time increases the rate of cell death, as reported by fitbook.de.
“Cancer occurs because cells go from a healthy state to a diseased state where they are constantly dividing. This happens when the cells have acquired a series of mutations and those mutations are selected. We found that aspirin (a brand of ASA) affects and slows down this training process, ”explains co-author Dominik Wodarz, professor of public health and disease prevention at the University of California.
Mathematical model for making general predictions
Using a mathematical model, the scientists were able to make a broad population-level prediction of whether cell kinetics (processes of cell movement and reaction) were changed by ASA treatment. “We thought that slowed cancer development due to ASA (aspirin) must result from slowed cell development towards malignant change. What surprised us was that this mechanism was good enough in explaining the level of protection observed in the In other words, the predicted level was consistent with the protective effect observed in epidemiological studies on the human population, “explains lead author and mathematician Natalia Komarova.
And Dominik Wodarz adds: “This work is an example of how mathematical approaches can be very useful for understanding complex phenomena in cancer biology. Such insights could not have been obtained through experiments alone. It requires the collaboration of empirical biological work and the mathematics”.
Sources: fitbook.de, krebsgesellschaft.de
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